She was a diplomat with the Ministry of Foreign Affairs, Singapore for 15+ years. While at the Permanent Mission of Singapore to the United Nations (UN) in New York, she chaired UN negotiations as well as represented the Group of 77 and China in UN negotiations on sustainable development issues. She was also Deputy Permanent Representative for Singapore to the World Trade Organisation and World Intellectual Property Organisation in Geneva.

Ye-Min co-founded Negotiation Resolution, which trains negotiators to speak for a better world by balancing interests and global responsibility. She conducts workshops and lectures on negotiation and leadership in diplomacy, such as for the UN Institute for Training and Research, UN University, Singapore's Ministry of Foreign Affairs, Guyana’s Ministry of Foreign Affairs, Philippines Department of Health, Leiden University, Keio University, Johns Hopkins University School of Advanced International Studies, The Fletcher School at Tufts University, and The School of International and Public Affairs at Columbia University. Ye-Min is also an accredited mediator.

She co-authored "Negotiating at the United Nations: A Practitioner's Guide" (Routledge 2019), which is used as teaching material in various institutions. She was featured in The Hague Diplomacy Podcast on “Diplomacy and Multilateralism During & After COVID” (2021). She also co-authored the article “Diplomacy in the Virtual Era” for the Women’s Foreign Policy Group (2020).

Ye-Min did her undergraduate studies at Johns Hopkins University and Oxford University, and received her Master of International Public Policy from Johns Hopkins School of Advanced International Studies.